Chip liquid chromatography-inductively coupled plasma-mass spectrometry: A new hyphenated microfluidic instrument for metallomics - LP120200079
This project will develop the next generation of hyphenated microfluidic chip liquid chromatography-inductively coupled plasma-mass spectrometer (chipLC-ICP-MS) for metallomics. We will develop an interface to efficiently couple a chipLC system with an ICP-MS. A pneumatically-assisted nebuliser will be integrated within the ChipLC. This configuration will be superior to current nano-LC-ICP-MS instruments, notably by eliminating complicated, tedious capillary connectors. Incorporating 2 columns in chip configurations will enable multidimensional liquid chromatography separations. Outcomes will include a robust, highly sensitive and easy-to-use instrument for biological applications and Australian leadership in metallomic research.